User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse




Journal Article

Müller glial cell-provided cellular light guidance through the vital guinea-pig retina


Junek,  Stephan
Cortical development, Max Planck Institute of Experimental Medicine, Max Planck Society;
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Agte, S., Junek, S., Matthias, S., Ulbricht, E., Erdmann, I., Wurm, A., et al. (2011). Müller glial cell-provided cellular light guidance through the vital guinea-pig retina. Biophysical Journal, 101(11), 2611-2619.

Cite as: http://hdl.handle.net/11858/00-001M-0000-002E-1CFB-0
In vertebrate eyes, images are projected onto an inverted retina where light passes all retinal layers on its way to the photoreceptor cells. Light scattering within this tissue should impair vision. We show that radial glial (Muller) cells in the living retina minimize intraretinal light scatter and conserve the diameter of a beam that hits a single Muller cell endfoot. Thus, light arrives at individual photoreceptors with high intensity. This leads to an optimized signal/noise ratio, which increases visual sensitivity and contrast. Moreover, we show that the ratio between Muller cells and cones-responsible for acute vision-is roughly 1. This suggests that high spatiotemporal resolution may be achieved by each cone receiving its part of the image via its individual Muller cell-light guide.