English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Cerebellar-dependent learning in larval zebrafish

MPS-Authors
/persons/resource/persons207868

Aizenberg,  M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

/persons/resource/persons208206

Schuman,  E. M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Aizenberg, M., & Schuman, E. M. (2011). Cerebellar-dependent learning in larval zebrafish. The Journal of Neuroscience, 31(24), 8708-8712.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002E-1CF1-4
Abstract
Understanding how neuronal network activity contributes to memory formation is challenged by the complexity of most brain circuits and the restricted ability to monitor the activity of neuronal populations in vivo. The developing zebrafish (Danio rerio) is an animal model that circumvents these problems, because zebrafish larvae possess a rich behavioral repertoire and an accessible brain. Here, we developed a classical conditioning paradigm in which 6- to 8-d-old larvae develop an enhanced motor response to a visual stimulus (conditioned stimulus, CS) when it is paired with touch (unconditioned stimulus, US). Using in vivo calcium imaging we demonstrate that CS and US activate different subsets of neurons in the cerebellum; their activity, modulated by learning two-photon laser ablation, revealed that the cerebellum is involved in acquisition and extinction, but not the retention, of this memory.