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HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals

MPG-Autoren
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Müller,  F.
Neurochemistry Department, Max Planck Institute for Brain Research, Max Planck Society;

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Ivanova,  E.
Neuroanatomy Department, Max Planck Institute for Brain Research, Max Planck Society;

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Haverkamp,  S.
Neuroanatomical studies on retinal circuitry and synaptic mechanisms Group, Max Planck Institute for Brain Research, Max Planck Society;

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Zitation

Müller, F., Scholten, A., Ivanova, E., Haverkamp, S., Kremmer, E., & Kaupp, U. B. (2003). HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. European Journal of Neuroscience, 17(10), 2084-2096.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002E-1F1D-E
Zusammenfassung
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four HCN channel isoforms (HCN1-4) are expressed differentially in the retina. In particular, different classes of bipolar cells have a different inventory of HCN channels. We found no evidence for the formation of heterooligomeric HCN channels. HCN channels are densely clustered at synaptic terminals of bipolar cells and photoreceptors. This suggests that HCN channels are involved in the control of transmitter release.