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Self-organization in development, regeneration and organoids

MPG-Autoren
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Werner,  Steffen
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Zitation

Werner, S., Hanh Vu, T.-K., & Rink, J. C. (2017). Self-organization in development, regeneration and organoids. Current Opinion in Cell Biology, 44, 102-109. doi:10.1016/j.ceb.2016.09.002.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002D-B94C-D
Zusammenfassung
Self-organization of cells is a fundamental design principle in biology, yet the inherent non-linearity of self-organizing systems often poses significant challenges in deciphering the underlying mechanisms. Here, we discuss recent progress in this respect, focusing on examples from development, regeneration and organoid differentiation. Together, these three paradigms emphasize the active material properties of tissues that result from the functional coupling between individual cells as active units. Further, we discuss the challenge of obtaining reproducible outcomes on the basis of self-organizing systems, which development and regeneration, but not the current organoid culture protocols, achieve.