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Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans

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Chintalapati,  Manjusha
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society;
Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Dannemann,  Michael
The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Prüfer,  Kay
Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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Zitation

Chintalapati, M., Dannemann, M., & Prüfer, K. (2017). Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans. BMC Evolutionary Biology, 17(1): 179. doi:10.1186/s12862-017-1018-8.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002D-B9F7-D
Zusammenfassung
Small insertions and deletions occur in humans at a lower rate compared to nucleotide changes, but evolve under more constraint than nucleotide changes. While the evolution of insertions and deletions have been investigated using ape outgroups, the now available genome of a Neandertal can shed light on the evolution of indels in more recent times.