Different forms of AMPA receptor mediated LTP and their correlation to the 
spatial working memory formation

Shimshek, Derya R.; Bus, Thorsten; Schupp, Bettina; Jensen, Vidar; Marx, Verena; Layer, Liliana E.; Köhr, Georg; Sprengel, Rolf

doi:10.3389/fnmol.2017.00214

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学術論文

Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation

MPS-Authors

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Shimshek, Derya R.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Bus, Thorsten
Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons95249

Schupp, Bettina
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons123282

Marx, Verena
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Layer, Liliana E.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Köhr, Georg
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel, Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00214/pdf
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https://doi.org/10.3389/fnmol.2017.00214
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引用

Shimshek, D. R., Bus, T., Schupp, B., Jensen, V., Marx, V., Layer, L. E., Köhr, G., & Sprengel, R. (2017). Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation. Frontiers in Molecular Neuroscience, 10:, pp. 1-11. doi:10.3389/fnmol.2017.00214.

引用: https://hdl.handle.net/11858/00-001M-0000-002D-C931-4

要旨

Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knockout mice LTP and SWM deficits could be partially recovered by transgenic re-installation of full-length GluA1 in principle forebrain neurons. Here we partially restored hippocampal LTP in GluA1-deficient mice by forebrain-specific depletion of the GluA2 gene, by the activation of a hypomorphic GluA2(Q) allele and by transgenic expression of PDZ-site truncated GFP-GluA1(TG). In none of these three mouse lines, the partial LTP recovery improved the SWM performance of GluA1-deficient mice suggesting a specific function of intact GluA1/2 receptors and the GluA1 intracellular carboxyl-terminus in SWM and its associated behavior.