Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Universal proximity effect in target search kinetics in the few-encounter limit.

MPG-Autoren
/persons/resource/persons206062

Godec,  A.
Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)

2472241.pdf
(Verlagsversion), 533KB

Ergänzendes Material (frei zugänglich)

2472241_Suppl.pdf
(Ergänzendes Material), 508KB

Zitation

Godec, A., & Metzler, R. (2016). Universal proximity effect in target search kinetics in the few-encounter limit. Physical Review X, 6(4): 041037. doi:10.1103/PhysRevX.6.041037.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002D-CAB2-9
Zusammenfassung
When does a diffusing particle reach its target for the first time? This first-passage time (FPT) problem is central to the kinetics of molecular reactions in chemistry and molecular biology. Here, we explain the behavior of smooth FPT densities, for which all moments are finite, and demonstrate universal yet generally non-Poissonian long-time asymptotics for a broad variety of transport processes. While Poisson-like asymptotics arise generically in the presence of an effective repulsion in the immediate vicinity of the target, a time-scale separation between direct and reflected indirect trajectories gives rise to a universal proximity effect: Direct paths, heading more or less straight from the point of release to the target, become typical and focused, with a narrow spread of the corresponding first-passage times. Conversely, statistically dominant indirect paths exploring the entire system tend to be massively dissimilar. The initial distance to the target particularly impacts gene regulatory or competitive stochastic processes, for which few binding events often determine the regulatory outcome. The proximity effect is independent of details of the transport, highlighting the robust character of the FPT features uncovered here.