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Fibronectins containing extradomain A or B enhance osteoblast differentiation via distinct integrins

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Sens,  Carla
Nakchbandi, Inaam / Translational Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Huck,  Katrin
Nakchbandi, Inaam / Translational Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Pettera,  Stefan
Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Uebel,  Stephan
Scientific Service Groups, Max Planck Institute of Biochemistry, Max Planck Society;

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Moser,  Markus
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Nakchbandi,  Inaam
Nakchbandi, Inaam / Translational Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Sens, C., Huck, K., Pettera, S., Uebel, S., Wabnitz, G., Moser, M., et al. (2017). Fibronectins containing extradomain A or B enhance osteoblast differentiation via distinct integrins. Journal of Biological Chemistry, 292(19), 7745-7760. doi:10.1074/jbc.M116.739987.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-E1D9-0
Abstract
Fibronectin is a multidomain protein secreted by various cell types. It forms a network of fibers within the extracellular matrix and impacts intracellular processes by binding to various molecules, primarily integrin receptors on the cells. Both the presence of several isoforms and the ability of the various domains and isoforms to bind to a variety of integrins result in a wide range of effects. In vivo findings suggest that fibronectin isoforms produced by the osteoblasts enhance their differentiation. Here we report that the isoform characterized by the presence of extradomain A activates alpha 4 beta 1 integrin and augments osteoblast differentiation. In addition, the isoform containing extradomain B enhances the binding of fibronectin through the RGD sequence to beta 3-containing integrin, resulting in increased mineralization by and differentiation of osteoblasts. Our study thus reveals novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation.