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Journal Article

AIDing-targeted protein degradation in Drosophila

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Zhang,  Xu
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Schnorrer,  Frank
Schnorrer, Frank / Muscle Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Zhang, X., & Schnorrer, F. (2017). AIDing-targeted protein degradation in Drosophila. The FEBS Journal, 284(8), 1178-1181. doi:10.1111/febs.14054.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-001A-B
Abstract
Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).