Insulin - a persistent synthetic challenge.

Moroder, Luis; Musiol, Hans-Jürgen

doi:10.1002/anie.201702493

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Insulin - a persistent synthetic challenge.

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Moroder, Luis
Moroder, Luis / Bioorganic Chemistry, Max Planck Institute of Biochemistry, Max Planck Society;

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Musiol, Hans-Jürgen
Moroder, Luis / Bioorganic Chemistry, Max Planck Institute of Biochemistry, Max Planck Society;

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Moroder, L., & Musiol, H.-J. (2017). Insulin - a persistent synthetic challenge. Angewandte Chemie International Edition, 56(36), 10656 -10669. doi:10.1002/anie.201702493.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-EED9-8

Abstract

After a short historical overview from the discovery to production of insulin from animal sources, later via semi-synthesis and finally rDNA-based expression, the review focuses on the most recent advances of chemical synthesis that progressively sur-mounted all technical obstacles of assembling heterodimeric structures crosslinked by intra- and intermolecular disulfides via biomimetic insulin precursors in the search for analogues of improved therapeutic properties. 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.