Impairment in predictive processes during auditory mismatch negativity in ScZ: 
Evidence from event-related fields

Sauer, Andreas; Zeev-Wolf, Maor; Grent-’t-Jong, Tineke; Recasens, Marc; Wacongne, Catherine; Wibral, Michael; Helbling, Saskia; Peled, Abraham; Grinshpoon, Alexander; Singer, Wolf; Goldstein, Abraham; Uhlhaas, Peter J.

doi:10.1002/hbm.23716

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Impairment in predictive processes during auditory mismatch negativity in ScZ: Evidence from event-related fields

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Sauer, Andreas
Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany;
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;

Singer, Wolf
Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany;
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;
Frankfurt Institute for Advanced Studies, Goethe University, Frankfurt;

Uhlhaas, Peter J.
Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt, Germany;
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;
Institute of Neuroscience and Psychology, University of Glasgow, United Kingdom;

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Citation

Sauer, A., Zeev-Wolf, M., Grent-’t-Jong, T., Recasens, M., Wacongne, C., Wibral, M., et al. (2017). Impairment in predictive processes during auditory mismatch negativity in ScZ: Evidence from event-related fields. Human Brain Mapping, 38(10), 5082-5093. doi:10.1002/hbm.23716.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-DA1C-F

Abstract

Patients with schizophrenia (ScZ) show pronounced dysfunctions in auditory perception but the underlying mechanisms as well as the localization of the deficit remain unclear. To examine these questions, the current study examined whether alterations in the neuromagnetic mismatch negativity (MMNm) in ScZ-patients could involve an impairment in sensory predictions in local sensory and higher auditory areas. Using a whole-head MEG-approach, we investigated the MMNm as well as P300m and N100m amplitudes during a hierarchical auditory novelty paradigm in 16 medicated ScZ-patients and 16 controls. In addition, responses to omitted sounds were investigated, allowing for a critical test of the predictive coding hypothesis. Source-localization was performed to identify the generators of the MMNm, omission responses as well as the P300m. Clinical symptoms were examined with the positive and negative syndrome scale. Event-related fields (ERFs) to standard sounds were intact in ScZ-patients. However, the ScZ-group showed a reduction in the amplitude of the MMNm during both local (within trials) and global (across trials) conditions as well as an absent P300m at the global level. Importantly, responses to sound omissions were reduced in ScZ-patients which overlapped both in latency and generators with the MMNm sources. Thus, our data suggest that auditory dysfunctions in ScZ involve impaired predictive processes that involve deficits in both automatic and conscious detection of auditory regularities.