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pH-based one pot synthesis of biocompatible olive shaped inorganic particles.

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Godec,  A.
Research Group of Mathematical Biophysics, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Znidarsic, A., Godec, A., & Gaberscek, M. (2012). pH-based one pot synthesis of biocompatible olive shaped inorganic particles. Materials Research Bulletin, 47(4), 967-973. doi:10.1016/j.materresbull.2012.01.010.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-D1E3-8
Abstract
A novel, single-step, one-pot method for preparation of inorganic hollow particles is introduced. The concept is grounded on the classical theory of nucleation of growth and can be carried out entirely at room temperature. Starting from an appropriate solution, precipitation and selective dissolution of inorganic nanoparticles are triggered by continuous addition of a salt while carefully controlling the pH. The approach is demonstrated on the example of hollow calcium phosphate particles using calcium carbonate solid nanoparticles as a template. The proposed synthesis procedure is simple and cheap and can be extended to other biocompatible compounds. It also can be upgraded with an additional in situ step