English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Actin protects mammalian eggs against chromosome segregation errors.

MPS-Authors
/persons/resource/persons203567

Mogessie,  B.
Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons188399

Schuh,  M.
Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

2473300.pdf
(Publisher version), 3MB

Supplementary Material (public)

2473300_Suppl_1.DC1
(Supplementary material), 59KB

2473300_Suppl_2.htm
(Supplementary material), 98KB

Citation

Mogessie, B., & Schuh, M. (2017). Actin protects mammalian eggs against chromosome segregation errors. Science, 357(6353): eaal1647. doi:10.1126/science.aal1647.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-D237-6
Abstract
Aneuploidy is a cellular condition characterized by the gain or loss of specific chromosomes. This can arise from chromosome segregation problems during cell division in the germ line (a process called meiosis), and is the main cause of age-related female infertility, spontaneous miscarriage, and developmental disorders in humans. To segregate chromosomes, cells rely on a spindle-shaped structure made up of filaments called microtubules. On page 772 of this issue, Mogessie and Schuh (1) show that another cytoskeleton filament—actin—can be found in close association with microtubules in the spindle and promotes chromosome segregation fidelity during meiosis in mammalian oocytes.