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The inhibition by β-adrenoceptor blocking agents of calcium uptake into and efflux from isolated sarcoplasmic vesicles

MPG-Autoren
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Hasselbach,  Wilhelm
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Makinose,  Madoka
Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

https://link.springer.com/content/pdf/10.1007%2FBF00499033.pdf
(beliebiger Volltext)

https://doi.org/10.1007/BF00499033
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Zitation

Temple, D. M., Hasselbach, W., & Makinose, M. (1974). The inhibition by β-adrenoceptor blocking agents of calcium uptake into and efflux from isolated sarcoplasmic vesicles. Naunyn-Schmiedeberg's Archives of Pharmacology, 39, 187-194. doi:10.1007/BF00499033.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002D-DF67-1
Zusammenfassung
The rates of calcium uptake and the calcium dependent increase in ATPase activity of sarcoplasmic reticulum vesicles isolated from rabbit skeletal muscle are reduced in the same ratio by the β-adrenoceptor blocking agents propranolol, pronethalol and Ro-03,3528, but neither by practolol, sotalol nor oxprenolol. The total calcium accumulated was affected by none of the inhibitors. The inhibitory potency of these compounds upon the calcium pump appears to be correlated with their membrane activity or potency as local anaesthetic agents, rather than with their β-adrenoceptor blocking potency. Like the rate of calcium uptake the rate of calcium efflux from the sarcoplasmic vesicles in the presence of ADP, GPD and UDP together with phosphate is inhibited by propranolol and pronethalol.