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Geometric analysis of macromolecule organization within cryo-electron tomograms

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Kuhn Cuellar,  Luis Eugenio
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Kuhn_Luis_PhD_thesis.pdf
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Citation

Kuhn Cuellar, L. E. (2017). Geometric analysis of macromolecule organization within cryo-electron tomograms. PhD Thesis, Technische Universität, München.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-E31C-C
Abstract
Cryo-electron tomography (CET) provides unprecedented views into the native cellular environment at molecular resolution. While subtomogram analysis yields high-resolution native structures of molecular complexes, it also determines the precise positions and orientations of these macromolecules within the cell. Analyzing the geometric relationships between adjacent macromolecules can offer structural insights into molecular interactions and identify supramolecular ensembles. However, computation...