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A forceful connection: mechanoregulation of oncogenic YAP

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Böttcher,  Ralph Thomas
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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Fässler,  Reinhard
Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society;

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2467.full.pdf
(Publisher version), 571KB

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Citation

Böttcher, R. T., Sun, Z., & Fässler, R. (2017). A forceful connection: mechanoregulation of oncogenic YAP. The EMBO Journal, 36(17), 2467-2469. doi:10.15252/embj.201797527.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002E-0001-1
Abstract
The Yes-associated protein (YAP) is an important transcriptional co-activator that mediates the cellular response to mechanical and cytoskeletal cues. In two recent papers published in The EMBO Journal, Dae-Sik Lim and colleagues show how YAP activity affects cancer formation and metastasis via a crosstalk with myocardin-related transcription factors (MRTFs; Kim et al, 2017) and SKP2-dependent cell cycle progression