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An ultrastructural analysis of electromotor cell death in Torpedo marmorata and its counterpart in vitro.

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Fox,  G.
Research Group of Electron Microscopy, MPI for biophysical chemistry, Max Planck Society;

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Fox, G., Kirk, C., & Richardson, G. P. (1988). An ultrastructural analysis of electromotor cell death in Torpedo marmorata and its counterpart in vitro. Cell and Tissue Research, 254(2), 455-464.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-EE60-7
Abstract
Naturally occurring neuronal cell death has been investigated in the electromotor system of Torpedo marmorata and compared with neuronal death seen in explant cultures of tissues from T. marmorata electric lobe. One objective of the study was to determine whether cell death in vitro was morphologically the same as cell death in vivo and to substantiate the validity of using in vitro models for studying naturally occurring cell death. Sequences of degeneration in vitro and in vivo have been established and compared: a single morphological sequence best represents this form of cell death in both conditions. In vivo, dying neurons are seen at all depths of the electric lobe indicating the involvement of different generations. Retrograde degeneration appears to be the first sign of cell death.