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Increased retention of calcium in the dendrites of long-term potentiated CA1 neurons of the hippocampal slice. A combined electrophysiological and electron histochemical study.

MPG-Autoren
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Kuhnt,  U.
Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society;

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Mihaly,  A.
Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society;

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Siklos,  L.
Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society;

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Zitation

Kuhnt, U., Mihaly, A., Siklos, L., & Joo, F. (1988). Increased retention of calcium in the dendrites of long-term potentiated CA1 neurons of the hippocampal slice. A combined electrophysiological and electron histochemical study. Histochemistry, 90(3), 185-193. doi:10.1007/BF00492506.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002D-F367-E
Zusammenfassung
In view of the importance of calcium in the induction of long-term potentiation (LTP), experiments were carried out to localize calcium at the electron microscopic level in the CA1 region of guinea pig hippocampal slices, following high-frequency stimulation of the Schaffer collaterals. Apart from the ultrastructural localization, a semi-quantitative method was used to count the calcium-containing deposits in electron micrographs. Significantly more calcium-containing deposits were seen in the dendrites of the stratum radiatum in slices with LTP than in those without it. A moderate increase of the extradendritic deposits was observed, too. The calcium content of the deposits was determined by means of EGTA incubation and X-ray analysis. The presented results, together with the relevant literature data, underline the importance of calcium-activated processes in postsynaptic structures probably involved in the generation of LTP.