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Amanitin poisoning in the dog

MPS-Authors
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Faulstich,  Heinz
Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society;

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Fauser,  U.
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Faulstich, H., & Fauser, U. (1975). Amanitin poisoning in the dog. In D. Keppler (Ed.), Pathogenesis and Mechanisms of Liver Cell Necrosis (pp. 69-74). [Lancaster]: MTP.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-FC88-F
Abstract
So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and 3[H]demethyl-O-methyl-γ-amanitin. Both these compounds exhibit shortcomings in in vivo experiments. O-methyl-γ- amanitin is as toxic as α-amanitin, the label, but undergoes microsomal oxidation. The second compound is probably stable under in vivo conditions but is 15 times less toxic, and, as we know from the experiments of Chambon’s laboratory1, binds 10 times less effectively to RNA-polymerase. We decided upon the first, more toxic compound.