Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

FACIL: Fast and Accurate Genetic Code Inference and Logo


Strous,  M.
Microbial Fitness Group, Max Planck Institute for Marine Microbiology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 545KB

Supplementary Material (public)
There is no public supplementary material available

Dutilh, B. E., Jurgelenaite, R., Szklarczyk, R., van Hijum, S. A. F. T., Harhangi, H. R., Schmid, M., et al. (2011). FACIL: Fast and Accurate Genetic Code Inference and Logo. Bioinformatics, 27(14), 1929-1933.

Cite as: https://hdl.handle.net/21.11116/0000-0001-C941-3
Motivation: The intensification of DNA sequencing will increasingly unveil uncharacterized species with potential alternative genetic codes. A total of 0.65% of the DNA sequences currently in Genbank encode their proteins with a variant genetic code, and these exceptions occur in many unrelated taxa.

Results: We introduce FACIL (Fast and Accurate genetic Code Inference and Logo), a fast and reliable tool to evaluate nucleic acid sequences for their genetic code that detects alternative codes even in species distantly related to known organisms. To illustrate this, we apply FACIL to a set of mitochondrial genomic contigs of Globobulimina pseudospinescens. This foraminifer does not have any sequenced close relative in the databases, yet we infer its alternative genetic code with high confidence values. Results are intuitively visualized in a Genetic Code Logo.