Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood


Schlotz,  Wolff
Scientific Services, Max Planck Institute for Empirical Aesthetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 312KB

Supplementary Material (public)
There is no public supplementary material available

Kumsta, R., Schlotz, W., Golm, D., Moser, D., Kennedy, M., Knights, N., et al. (2017). HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood. Psychoneuroendocrinology, 86, 196-202. doi:10.1016/j.psyneuen.2017.09.021.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-FE65-D
Hypothalamic–pituitary–adrenal (HPA) axis function is disrupted in institutionally-deprived children – reduced morning cortisol, flattened diurnal slope and blunted reactivity persist even after successful adoption into positive family environments. Here we test whether such effects persist into adulthood. Cortisol release across the day (sampled at awakening, 30 and 45min later, and at four points across the day) was investigated in young adult adoptees who had lived in severe deprivation for up to 43 months in early childhood in Ceaușescu’s Romanian orphanages and a comparison group of non-deprived UK adoptees (Total N=57; mean age=24±0.9years). The mediating role of cortisol levels on adult mental health was examined using data from standardized clinical assessments. Cortisol profiles were disrupted in the Romanian adoptees who experienced more than 6 months deprivation marked by a striking absence of the cortisol awakening response (CAR) and a significantly flatter cortisol curve until 1h 15min after awakening. Whereas institutional deprivation was associated with both cortisol secretion and emergence of emotional problems in young adulthood, path analysis revealed no evidence for a mediating role of CAR disruption in the sub-sample studied here. The results are in line with findings of HPA axis hypo-functionality following early adverse experience and provide strong evidence for long-term programming effects of HPA axis function through experience of institutional deprivation.