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Journal Article

Pressure effects on collective density fluctuations in water and protein solutions


Heyden,  Matthias
Research Group Heyden, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Russo, D., Laloni, A., Filabozzi, A., & Heyden, M. (2017). Pressure effects on collective density fluctuations in water and protein solutions. Proceedings of the National Academy of Sciences of the United States of America, 114(43), 11410-11415. doi:10.1073/pnas.1705279114.

Cite as: https://hdl.handle.net/21.11116/0000-0000-31C8-7
Neutron Brillouin scattering and molecular dynamics simulations have been used to investigate protein hydration water density fluctuations as a function of pressure. Our results show significant differences between the pressure and density dependence of collective dynamics in bulk water and in concentrated protein solutions. Pressure-induced changes in the tetrahedral order of the water HB network have direct consequences for the high-frequency sound velocity and damping coefficients, which we find to be a sensitive probe for changes in the HB network structure as well as the wetting of biomolecular surfaces.