Vitamin C: C-ing a New Way to Fight Leukemia

Schönberger, Katharina; Cabezas-Wallscheid, Nina

doi:10.1016/j.stem.2017.09.015

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Journal Article

Vitamin C: C-ing a New Way to Fight Leukemia

MPS-Authors

Schönberger, Katharina
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Schönberger, K., & Cabezas-Wallscheid, N. (2017). Vitamin C: C-ing a New Way to Fight Leukemia. Cell Stem Cell, 21, 561-563. doi:10.1016/j.stem.2017.09.015.

Cite as: http://hdl.handle.net/11858/00-001M-0000-002E-8595-A

Abstract

Metabolic cues and (epi-)genetic factors are emerging regulators of hematopoietic stem cell (HSC) potency. Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses leukemogenesis by modulating Tet2 activity.