Segmental duplications and evolutionary acquisition of UV damage response in 
the SPATA31 gene family of primates and humans

Bekpen, Cemalettin; Künzel, Sven; Xie, Chen; Eaaswarkhanth, Muthukrishnan; Lin, Yen-Lung; Gokcumen, Omer; Akdis, Cezmi A.; Tautz, Diethard

doi:10.1186/s12864-017-3595-8

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Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans

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Bekpen, Cemalettin
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Künzel, Sven
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Xie, Chen
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Tautz, Diethard
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Bekpen, C., Künzel, S., Xie, C., Eaaswarkhanth, M., Lin, Y.-L., Gokcumen, O., et al. (2017). Segmental duplications and evolutionary acquisition of UV damage response in the SPATA31 gene family of primates and humans. BMC Genomics, 18: 222. doi:10.1186/s12864-017-3595-8.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-904C-2

Abstract

Segmental duplications are an abundant source for novel gene functions and evolutionary adaptations. This mechanism of generating novelty was very active during the evolution of primates particularly in the human lineage. Here, we characterize the evolution and function of the SPATA31 gene family (former designation FAM75A), which was previously shown to be among the gene families with the strongest signal of positive selection in hominoids. The mouse homologue for this gene family is a single copy gene expressed during spermatogenesis.