GABA quantitation using MEGA-PRESS: Regional and hemispheric differences

Grewal, Monika; Dabas, Aroma; Saharan, Sumiti; Barker, Peter B.; Edden, Richard A.E.; Mandal, Pravat K.

doi:10.1002/jmri.25324

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

GABA quantitation using MEGA-PRESS: Regional and hemispheric differences

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

epdf
(Publisher version), 10KB

Supplementary Material (public)

There is no public supplementary material available

Citation

Grewal, M., Dabas, A., Saharan, S., Barker, P. B., Edden, R. A., & Mandal, P. K. (2016). GABA quantitation using MEGA-PRESS: Regional and hemispheric differences. Journal of Magnetic Resonance Imaging, 44(6), 1619-1623. doi:10.1002/jmri.25324.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-A0A7-A

Abstract

Purpose

To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional and hemispheric differences, using MR spectroscopy (1H-MRS).
Materials and Methods

GABA concentrations were measured bilaterally in the frontal cortex (FC), parietal cortex (PC), and occipital cortex (OC) of 21 healthy young subjects (age range 20–29 years) using 3 Tesla Philips scanner. A univariate general linear model analysis was carried out to assess the effect of region and hemisphere as well as their interaction on GABA concentrations while controlling for sex and gray matter differences.
Results

Results indicated a significant regional dependence of GABA levels [F(2,89) = 11.725, P < 0.001, inline image = .209] with lower concentrations in the FC compared with both PC (P < 0.001) and OC (P < 0.001) regions. There was no significant hemispheric differences in GABA levels [F(1,89) = .172; P = 0.679; inline image = .002].
Conclusion

This study reports the concentrations of GABA in the FC, PC, and OC brain regions of healthy young adults. GABA distribution exhibits hemispheric symmetry, but varies across regions; GABA levels in the FC are lower than those in the PC and OC.