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Journal Article

18F‑Deoxyfluorination of Phenols via Ru π‑Complexes

MPS-Authors
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Chen,  Junting
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Ritter,  Tobias
Department for Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA;
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital;

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Citation

Beyzavi, M. H., Mandal, D., Strebl, M. G., Neumann, C. N., D'Amato, E. M., Chen, J., et al. (2017). 18F‑Deoxyfluorination of Phenols via Ru π‑Complexes. ACS Central Science, 3(9), 944-948. doi:10.1021/acscentsci.7b00195.


Cite as: https://hdl.handle.net/21.11116/0000-0000-77A1-4
Abstract
The deficiency of robust and practical methods
for 18F-radiofluorination is a bottleneck for positron emission
tomography (PET) tracer development. Here, we report the
first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as
starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to
generate doses appropriate for PET imaging.