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GluR-A-Dependent Synaptic Plasticity Is Required for the Temporal Encoding of Nonspatial Information

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society;
Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Reisel, D., Bannerman, D. M., Deacon, R. M. J., Sprengel, R., Seeburg, P. H., & Rawlins, J. N. P. (2005). GluR-A-Dependent Synaptic Plasticity Is Required for the Temporal Encoding of Nonspatial Information. Behav. Neurosci., 119(5), 1298-1306. doi:10.1037/0735-7044.119.5.1298.


Zitierlink: http://hdl.handle.net/21.11116/0000-0000-3829-4
Zusammenfassung
Four related experiments studied operant performance of mice on differential reinforcement of low rates of responding (DRL) paradigms. Experiment 1 showed that excitotoxic hippocampal lesions impaired performance of a 10-s DRL schedule (DRL-10). Experiments 2 and 3 showed that GluR-A AMPA receptor subunit knockout mice, which are deficient in CA3-CA1 long-term potentiation (LTP), were markedly impaired at 15 s (DRL-15), but less impaired at DRL-10. Experiment 4 compared DRL-15 performance in mice from the 2 strains from which the GluR-A colony was derived and showed that they did not differ. The results show that GluR-A-containing AMPA receptors are required for normal performance on hippocampus-dependent, nonspatial working memory tasks, consistent with a role for GluR-A in the temporal encoding (what happened when) of nonspatial information.