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Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure

MPG-Autoren
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Grinevich,  Valery
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Poskrebysheva, A. S., Grinevich, V., Smurova, I. V., Shostak, N. A., & Akmayev, I. G. (2003). Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure. Uspechi fiziologiceskich nauk, 34(3), 3-20. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12942758.


Zitierlink: https://hdl.handle.net/21.11116/0000-0000-3C65-C
Zusammenfassung
Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromonal approach in CHF treatment is on the whole rather unsatisfactory. Recently the interest of clinical investigators has been focused on immune mechanisms in the pathogenesis of CHF. In this review we tried to summarize data concerning contribution of inflammatory cytokines to pathogenesis of CHF. The source and site of action of pro- and antiinflammatory cytokines and number of interactions among cytokines and neuroendocrine systems under CHF are considered. Finally we discuss novel therapies managing correction of both immune and neurohormonal status of the patient.