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Defining B Cell Chromatin: Lessons from EBF1

MPG-Autoren

Boller,  Sören
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Li,  Rui
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Grosschedl,  Rudi
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Zitation

Boller, S., Li, R., & Grosschedl, R. (2018). Defining B Cell Chromatin: Lessons from EBF1. Trends in Genetics, 257-269. doi:10.1016/j.tig.2017.12.014.


Zitierlink: http://hdl.handle.net/21.11116/0000-0001-4A45-F
Zusammenfassung
Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.