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Delineating the Transcriptional Mechanisms in Immunity behind Allergy and Asthma: Milestones and Challenges Ahead

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Cauchy,  Pierre
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Cauchy, P. (2017). Delineating the Transcriptional Mechanisms in Immunity behind Allergy and Asthma: Milestones and Challenges Ahead. International Journal of Allergy & Asthma, 1-15. doi:10.29011/IJAA-101.


Cite as: http://hdl.handle.net/21.11116/0000-0000-C15D-E
Abstract
Allergy and asthma have roots in imbalances in immune cell homeostasis, namely a shift towards T-helper 2 (T)h2)-driven increases of Immunoglobulin E (IgE) immunity. Here, we describe the transcriptional processes that lead to the emergence of the immunological actors of allergy and asthma, i.e. Th2, type 2 Innate Lymphoid Cells (ILC2), mast, IgE plasma and regulatory T-cells (reg), as well as to the advent of imbalances towards Th2 responses in pathological cases. We review in detail the latest advance in terms of genome-wide characterisation of the transcriptional landscapes of the protagonists of allergy and asthma, both in norma and pathological contexts if available, as well as a summary of current clinical approaches and discuss the requirement for further functional-based genome-wide characterisation of mechanisms that can lead to the attenuation of these conditions.