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In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons

MPG-Autoren
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Helmchen,  Fritjof
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;
In Vivo Microscopy of Cortical Dynamics, Max Planck Institute for Medical Research, Max Planck Society;
Cortical Two Photon Imaging, Max Planck Institute for Medical Research, Max Planck Society;

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Denk,  Winfried
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Helmchen, F., Svoboda, K., Denk, W., & Tank, D. W. (1999). In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature Neuroscience, 2(11), 989-996. doi:10.1038/14788.


Zitierlink: http://hdl.handle.net/21.11116/0000-0000-4042-D
Zusammenfassung
Dendritic Ca2+ action potentials in neocortical pyramidal neurons have been characterized in brain slices, but their presence and role in the intact neocortex remain unclear. Here we used two-photon microscopy to demonstrate Ca2+ electrogenesis in apical dendrites of deep-layer pyramidal neurons of rat barrel cortex in vivo. During whisker stimulation, complex spikes recorded intracellularly from distal dendrites and sharp waves in the electrocorticogram were accompanied by large dendritic [Ca2+ ] transients; these also occurred during bursts of action potentials recorded from somata of identified layer 5 neurons. The amplitude of the [Ca 2+] transients was largest proximal to the main bifurcation, where sodium action potentials produced little Ca2+ influx. In some cases, synaptic stimulation evoked [Ca2+] transients without a concomitant action potential burst, suggesting variable coupling between dendrite and soma.