Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Mutual synchronization of molecular turnover cycles in allosteric enzymes II. product inhibition

MPG-Autoren
/persons/resource/persons95456

Stange,  Pedro
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons93404

Hess,  Benno
Emeritus Group Prof. Dr. B. Hess, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Stange, P., Mikhailov, A. S., & Hess, B. (1999). Mutual synchronization of molecular turnover cycles in allosteric enzymes II. product inhibition. The Journal of Physical Chemistry B, 103(29), 6111-6210. doi:10.1021/jp9900640.


Zitierlink: http://hdl.handle.net/21.11116/0000-0000-55FA-7
Zusammenfassung
Diffusion of regulatory molecules during an enzymic reaction in micrometer and submicrometer reaction volumes can lead to mixing and transport times much shorter than the turnover time of enzymes. Our theoretical investigations of a stochastic model of an allosterically product-inhibited enzymic reaction show that under these conditions the turnover cycles of individual enzymes can become synchronized. Interactions between different enzymes realized by means of fast moving inhibitor molecules are responsible for such mutual synchronization. This synchronization is accompanied by rapid oscillations in the concentration of the reaction product.