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GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular cell layer

MPG-Autoren
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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Korpi, E. R., Lüddens, H., & Seeburg, P. H. (1992). GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular cell layer. European Journal of Pharmacology, 211(3), 427-428. doi:10.1016/0014-2999(92)90402-P.


Zitierlink: http://hdl.handle.net/21.11116/0000-0000-60DD-B
Zusammenfassung
Autoradiography revealed picrotoxin-sensitive [35S]TBPS ([35S]t-butylbicyclophosphorothionate) binding sites in the cerebellar granule cell layer only in the presence of GABAA receptor antagonists. However, under the same conditions, the binding was decreased in other brain regions, including the cerebellar molecular cell layer. Thus, the convulsant binding sites at GABAA receptors in the granule cell layer are highly sensitive to down-regulation by GABA, which may be due to a unique combination of receptor subunits.