GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular 
cell layer

Korpi, Esa R.; Lüddens, Hartmut; Seeburg, Peter H.

doi:10.1016/0014-2999(92)90402-P

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GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular cell layer

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Korpi, E. R., Lüddens, H., & Seeburg, P. H. (1992). GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular cell layer. European Journal of Pharmacology, 211(3), 427-428. doi:10.1016/0014-2999(92)90402-P.

Cite as: https://hdl.handle.net/21.11116/0000-0000-60DD-B

Abstract

Autoradiography revealed picrotoxin-sensitive [35S]TBPS ([35S]t-butylbicyclophosphorothionate) binding sites in the cerebellar granule cell layer only in the presence of GABAA receptor antagonists. However, under the same conditions, the binding was decreased in other brain regions, including the cerebellar molecular cell layer. Thus, the convulsant binding sites at GABAA receptors in the granule cell layer are highly sensitive to down-regulation by GABA, which may be due to a unique combination of receptor subunits.