Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium

Mishra, A; Jiang, Y; Roberts, S; Ntziachristos, V; Westmeyer, GG

doi:10.1021/acs.analchem.6b03039

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium

MPS-Authors

/persons/resource/persons84084

Mishra, A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214544

Jiang, Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

Link
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Mishra, A., Jiang, Y., Roberts, S., Ntziachristos, V., & Westmeyer, G. (2016). Near-Infrared Photoacoustic Imaging Probe Responsive to Calcium. Analytical Chemistry, 88(22), 10785-10789. doi:10.1021/acs.analchem.6b03039.

Cite as: https://hdl.handle.net/21.11116/0000-0000-7955-9

Abstract

Photoacoustic imaging (PAI) is an attractive imaging modality that can volumetrically map the distribution of photoabsorbing molecules with deeper tissue penetration than multiphoton microscopy. To enable dynamic sensing of divalent cations via PAI, we have engineered a new reversible near-infrared probe that is more sensitive to calcium as compared to other biologically relevant cations. The metallochromic compound showed a strong reduction of its peak absorbance at 765 nm upon addition of calcium ions that was translated into robust signal changes in photoacoustic images. Therefore, the heptamethine cyanine dye will be an attractive scaffold to create a series of metallochromic sensors for molecular PAI.