Evaluation of a Modified High-Definition Electrode Montage for Transcranial 
Alternating Current Stimulation (tACS) of Pre-Central Areas

Heise, K-F; Kortzorg, N; Bicalho Saturnino, G; Fujiyama, H; Cuypers, K; Thielscher, A; Swinnen, SP

doi:10.1016/j.brs.2016.04.009

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Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas

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Bicalho Saturnino, G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Thielscher, A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Heise, K.-F., Kortzorg, N., Bicalho Saturnino, G., Fujiyama, H., Cuypers, K., Thielscher, A., et al. (2016). Evaluation of a Modified High-Definition Electrode Montage for Transcranial Alternating Current Stimulation (tACS) of Pre-Central Areas. Brain Stimulation, 9(5), 700-704. doi:10.1016/j.brs.2016.04.009.

Cite as: https://hdl.handle.net/21.11116/0000-0000-7977-3

Abstract

Objective To evaluate a modified electrode montage with respect to its effect on tACS-dependent modulation of corticospinal excitability and discomfort caused by neurosensory side effects accompanying stimulation. Methods In a double-blind cross-over design, the classical electrode montage for primary motor cortex (M1) stimulation (two patch electrodes over M1 and contralateral supraorbital area) was compared with an M1 centre-ring montage. Corticospinal excitability was evaluated before, during, immediately after and 15 minutes after tACS (10 min., 20Hz vs. 30 sec. low-frequency transcranial random noise stimulation). Results Corticospinal excitability increased significantly during and immediately after tACS with the centre-ring montage. This was not the case with the classical montage or tRNS stimulation. Level of discomfort was rated on average lower with the centre-ring montage. Conclusions In comparison to the classic montage, the M1 centre-ring montage enables a more focal stimulation of the target area and, at the same time, significantly reduces neurosensory side effects, essential for placebo-controlled study designs.