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Motion correction and frequency stabilization for MRS of the human spinal cord

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Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Hock, A., & Henning, A. (2016). Motion correction and frequency stabilization for MRS of the human spinal cord. NMR in Biomedicine, 29(4), 490-498. doi:10.1002/nbm.3487.


Cite as: http://hdl.handle.net/21.11116/0000-0000-79F0-9
Abstract
Subject motion is challenging for MRS, because it can falsify results. For spinal cord MRS in particular, subject movement is critical, since even a small movement > 1 mm) can lead to a voxel shift out of the desired measurement region. Therefore, the identification of motion corrupted MRS scans is essential. In this investigation, MR navigators acquired simultaneously with the MRS data are used to identify a displacement of the spinal cord due to subject motion. It is shown that navigators are able to recognize substantial subject motion (>1 mm) without impairing the MRS measurement. In addition, navigators are easy to apply to the measurement, because no additional hardware and just a minor additional user effort are needed. Moreover, no additional scan time is required, because navigators can be applied in the deadtime of the MRS sequence. Furthermore, in this work, retrospective motion correction combined with frequency stabilization is presented by combining navigators with non-water-suppressed 1H-MRS, resulting in an improved spectral quality of the spinal cord measurements.