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Developing a Rat Model of Brainstem Coma: Initial MRI and MRA Investigations of Basilar Artery Occlusion

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Pais Roldán,  P
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pais Roldán, P., Edlow, B., & Yu, X. (2016). Developing a Rat Model of Brainstem Coma: Initial MRI and MRA Investigations of Basilar Artery Occlusion. Poster presented at 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.


Cite as: http://hdl.handle.net/21.11116/0000-0000-7BB1-E
Abstract
The ascending reticular activating system (ARAS) of the brainstem mediates arousal, which is an essential component of consciousness. In order to infarct the ARAS and induce an unarousable state in rats, we performed a two-point basilar artery (BA) occlusion. We used high resolution MRI to map the neuroanatomical distribution of the resulting brainstem infarction and MRA to map the penetrating branches of the BA. BA occlusion reproducibly caused medial-ventral brainstem infarction but did not create an unarousable state, suggesting that a larger region of ARAS infarction will be needed to create a rat model of brainstem coma.