Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Meeting Abstract

Decipher the neuronal and astrocytic calcium signal coupling with fMRI

MPG-Autoren
/persons/resource/persons214940

Wang,  M
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192829

He,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

Link
(beliebiger Volltext)

Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Wang, M., He, Y., Engelmann, J., & Yu, X. (2016). Decipher the neuronal and astrocytic calcium signal coupling with fMRI. In 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law (pp. 12).


Zitierlink: http://hdl.handle.net/21.11116/0000-0000-7C65-4
Zusammenfassung
Functional magnetic resonance imaging (fMRI) based on blood oxygen level dependent (BOLD) signals reects the changes of oxy/deoxy-hemoglobin ratio in vessels. Simultaneous fMRI studies with electrophysiological recordings have demonstrated that BOLDfMRI signal correlated with neuronal activity (Logothetis et al. 2001). In addition, Schulz et al acquired fMRI and calcium (Ca2+) signal simultaneously through Ca2+ sensitive dyes (Schulz et al. 2012). Using the similar strategy, we expressed the genetically encoded calcium indicators (GCaMP6f) specifically in either neurons or astrocytes in the rat cortex. The cell-type specific Ca2+ signal showed different coupling features to the BOLD fMRI signal. In contrast to the highly correlated neuronal Ca2+ signal to the fMRI signal, the astrocytic Ca2+ signal presented two different coupling features to the fMRI signal. The evoked astrocytic Ca2+ signal remained positively correlated to fMRI signal, but spontaneous astrocytic Ca2+ signal was negatively correlated to the fMRI signal. Moreover, the spontaneous astrocytic Ca2+ signal could be elicited by stimulation through the whole cortex, which is highly correlated with activation of the mediodorsal and centrolateral thalamic nucleus. This work demonstrated a novel neuron-glia-vascular coupling event mediated through the spontaneous astrocytic calcium signal, which may indicate specific brain state changes.