Eine adiabatische Spin-Lock Methode für T1ρ-basierte dynamische 
Glukose-Bildgebung an Ultrahochfeld MR-Tomographen

Schuenke, P; Koehler, C; Korzowski, A; Windschuh, J; Bachert, P; Ladd, M; Mundiyanapurath, S; Paech, D; Bickelhaupt, S; Bonekamp, D; Schlemmer, H-P; Radbruch, A; Zaiss, M

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Eine adiabatische Spin-Lock Methode für T1ρ-basierte dynamische Glukose-Bildgebung an Ultrahochfeld MR-Tomographen

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Schuenke, P., Koehler, C., Korzowski, A., Windschuh, J., Bachert, P., Ladd, M., Mundiyanapurath, S., Paech, D., Bickelhaupt, S., Bonekamp, D., Schlemmer, H.-P., Radbruch, A., & Zaiss, M. (2016). Eine adiabatische Spin-Lock Methode für T1ρ-basierte dynamische Glukose-Bildgebung an Ultrahochfeld MR-Tomographen. In 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016) (pp. 38-41).

引用: https://hdl.handle.net/21.11116/0000-0000-7C6B-E

要旨

Chemical Exchange sensitive spin-lock (CESL) allows to observe the uptake of administered glucose in vivo; e.g. for tumor imaging. For application at ultra-high field whole-body scanners we implemented an adiabatic spin-lock sequence, which was shown to be insensitive to inhomogeneities in the RF field and thus leads to an improved image quality compared to conventional spin-lock. The sensitivity of the adiabatic spin-lock method was verified and for the first time a T1ρ-based dynamic glucose enhanced (DGE) contrast was observed in a brain tumor patient.