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Journal Article

A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor

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Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/0922410690902018/pdf?md5=cc6e55cbbc9cc4f38574ca851e0fc149&pid=1-s2.0-0922410690902018-main.pdf
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https://doi.org/10.1016/0922-4106(90)90201-8
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Citation

Lan, N. C., Chen, J.-S., Belleli, D., Pritchett, D. B., Seeburg, P. H., & Gee, K. (1990). A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. European Journal of Pharmacology, 88(6), 403-406. doi:10.1016/0922-4106(90)90201-8.


Cite as: https://hdl.handle.net/21.11116/0000-0000-7D8F-4
Abstract
Pregnane steroids, particularly 3 alpha-hydroxylated metabolites of progesterone, are known to have rapid and profound effects on brain excitability. Recent evidence suggests that the gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor-Cl- ionophore complex may mediate these actions. The data further suggest that these steroids modulate the complex through a novel site independent of other known sites on the complex. The hypothesis that this site is on the GABA(A)-benzodiazepine receptor-Cl- ionophore complex is tested in the present study by determining its presence on transiently expressed GABAA-benzodiazepine receptors.