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Journal Article

The role of receptor subtype diversity in the CNS


Seeburg,  Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Schofield, P. R., Shivers, B. D., & Seeburg, P. H. (1990). The role of receptor subtype diversity in the CNS. Trends in Neurosciences, 13(1), 8-11. doi:10.1016/0166-2236(90)90052-C.

Cite as: https://hdl.handle.net/21.11116/0000-0000-8435-F
The molecular characterization of neuroreceptors and voltage-gated ion channels has revealed that receptor subtype heterogeneity is a common feature of chemical and electrical signal reception. The use of distinct genes encoding receptor subtypes is a favoured mechanism for generation of this diversity. We propose that the significance of the multiplicity and diversity of signal reception proteins is to increase the information-handling capacity of neurons. This may contribute to neural plasticity.