Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Meeting Abstract

How microstructure changes are associated with gene deletions in psychiatric disorder


Kumar,  V
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Kumar, V. (2015). How microstructure changes are associated with gene deletions in psychiatric disorder. In Donders Discussions 2015 (pp. 22).

Cite as: https://hdl.handle.net/21.11116/0000-0000-887B-D
The genetic and epigenetic code of genes procreate the brain structure. Deletion of a single gene can lead to drastic structural changes that can be detected using diffusion MRI. In this study, we investigated structural changes occurred due to deletion of all genes located at locus 16p11.2 in mouse, which are believed to be involved in Schizophrenia. In addition, we hypothesized; male and female mice process the deletion similarly or differently.
Thus, to detect the specific white matter micro-structural changes in ultra-high spatial resolution a custom made MR coil was used. Also, the generic diffusion analysis pipeline was adapted for mice. The analysis revealed that deletion of the gene-locus leads to decrease in the fiber integrity in inter-hemispheric communication, which is convergent with gene expression.