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Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review

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Henning,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning, A. (2018). Proton and multinuclear magnetic resonance spectroscopy in the human brain at ultra-high field strength: A review. NeuroImage, 168, 181-198. doi:10.1016/j.neuroimage.2017.07.017.


Cite as: http://hdl.handle.net/21.11116/0000-0000-C2F1-4
Abstract
Magnetic Resonance Spectroscopy (MRS) allows for a non-invasive and non-ionizing determination of in vivo tissue concentrations and metabolic turn-over rates of more than 20 metabolites and compounds in the central nervous system of humans. The aim of this review is to give a comprehensive overview about the advantages, challenges and advances of ultra-high field MRS with regard to methodological development, discoveries and applications from its beginnings around 15 years ago up to the current state. The review is limited to human brain and spinal cord application at field strength of 7T and 9.4T and includes all relevant nuclei (1H, 31P, 13C).