English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Poster

NET-fMRI examination of the relation between the anterior insula and whole-brain activity in the macaque monkey

MPS-Authors
/persons/resource/persons84465

Klein,  C
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215913

Smuda,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84099

Murayama,  Y
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84237

Steudel,  T
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons85303

Krampe,  E
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84733

Oeltermann,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84309

Werner,  J
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis,  NK
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83908

Evrard,  HC
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Ressource

Link
(Any fulltext)

Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Klein, C., Smuda, J., Murayama, Y., Steudel, T., Krampe, E., Oeltermann, A., et al. (2017). NET-fMRI examination of the relation between the anterior insula and whole-brain activity in the macaque monkey. Poster presented at 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), Washington, DC, USA.


Cite as: http://hdl.handle.net/21.11116/0000-0000-C3E3-3
Abstract
The central representation and the goal-directed control of bodily states are integrated in the anterior insular cortex (AIC) as core processes underlying the ‘subjective’ component of emotion and cognition. The AIC is often regarded as a key “node” of the saliency network with a role in coordinating brain network activity upon the detection of homeostatic changes. A model proposed that the preferential representation of parasympathetic and sympathetic activity in the left and right AIC underlies appetitive and aversive emotions, respectively (Craig TICS 2005 9:566-71). Given the possible role of the AIC in switching brain network dynamics, we examined whether this asymmetry occurs in functional relation of the AIC with the rest of the brain. To this end we used multi contact laminar electrodes to record neural activity from the left and right AIC in parallel while simultaneously acquiring functional magnetic resonance imaging (fMRI) scans in four rhesus macaque monkeys. The electrodes were placed in the AIC area containing the von Economo neurons (or ‘VEN area’), an area shown previously to be larger and independently contain more VENs on the right than on the left side (Evrard et al. Neuron 2012 74:482-9). The ongoing spontaneous neuronal activity was analyzed focusing on the local field potential (LFP) gamma band (56-79 Hz) where frequent increases in amplitude could be observed. These gamma events were in most cases unilateral, with occurrence either in the left or in the right VEN area in the majority of the cases and only few cases where gamma band activity increased simultaneously on both sides. Following the detection of these gamma events, their occurrence was used to trigger and average the blood-oxygen-level dependent (BOLD) signal from the fMRI scans, a method called ‘neural-event-triggered fMRI’ (NET-fMRI) (Logothetis et al. Nature 2012 491:547-53). The examination and mapping of the BOLD signal change during asymmetric events revealed markedly different patterns of activation and deactivation in vast regions of the brain. These effects might substantiate a fundamental autonomic forebrain asymmetry balancing brain dynamics to produce nurturing and expending behaviors and feelings in a homeostatically optimal manner.