Dynamic Glucose Enhanced MRI: A prospective study in healthy volunteers and 
glioblastoma patients

Paech, D; Schuenke, P; Koehler, C; Windschuh, J; Mundiyanapurath, S; Bickelhaupt, S; Bäumer, P; Bonekamp, D; Bendszus, M; Wick, W; Bachert, P; Ladd, M; Schlemmer, H-P; Zaiss, M; Radbruch, A

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Dynamic Glucose Enhanced MRI: A prospective study in healthy volunteers and glioblastoma patients

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Zaiss, M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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引用

Paech, D., Schuenke, P., Koehler, C., Windschuh, J., Mundiyanapurath, S., Bickelhaupt, S., Bäumer, P., Bonekamp, D., Bendszus, M., Wick, W., Bachert, P., Ladd, M., Schlemmer, H.-P., Zaiss, M., & Radbruch, A. (2017). Dynamic Glucose Enhanced MRI: A prospective study in healthy volunteers and glioblastoma patients. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

引用: https://hdl.handle.net/21.11116/0000-0000-C48F-2

要旨

Glucose is the main energy source of cancer cells to proliferate and survive. Recently, promising results to assess changes in cellular metabolism using natural unlabeled D-glucose as biodegradable MRI contrast agent, have been reported employing Chemical Exchange Saturation Transfer (CEST) and Chemical Exchange sensitive Spin-Lock (CESL) imaging. In this work, the CESL-based dynamic glucose enhanced (DGE) contrast was investigated in healthy volunteers and a homogenous cohort of newly diagnosed untreated glioblastoma patients at 7 Tesla. DGE MRI allowed for sensitive visualization of physiological glucose uptake in the healthy human brain and pathophysiologically increased glucose enhancement of brain tumors.