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SQUID-based ultralow field nuclear magnetic resonance spectroscopy using the para-H2 based hyperpolarization technique SABRE

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Buckenmaier,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Rudolph,  M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214745

Rudin,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Scheffler,  K
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Buckenmaier, K., Rudolph, M., Back, C., Engelmann, J., Rudin, J., Misztal, T., et al. (2017). SQUID-based ultralow field nuclear magnetic resonance spectroscopy using the para-H2 based hyperpolarization technique SABRE. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.


Cite as: https://hdl.handle.net/21.11116/0000-0000-C4A1-C
Abstract
SABRE is a technique to achieve continuous hyperpolarization for MR measurements by the interaction of para-hydrogen and a substrate via steady ligand exchange on a catalyst. Thus, MR-active nuclei can be hyperpolarized more than only once. At field strengths of mT Faraday coils, commonly used in conventional or high field MRI, become insensitive and SQUIDs performing superior. Since SQUIDs are broadband detectors, the static magnetic field B0 can be changed easily or multiple nuclei can be measured simultaneously. Here, we successfully demonstrate the advantages of a SQUID based system by showing significant signal enhancement (1H, 19F) by hyperpolarization of 3-fluoropyridine.