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A novel role of intrinsic astrocytic calcium spikes to mediate brain states through central/dorsal thalamic nuclei

MPS-Authors
/persons/resource/persons214940

Wang,  M
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192829

He,  Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wang, M., He, Y., & Yu, X. (2017). A novel role of intrinsic astrocytic calcium spikes to mediate brain states through central/dorsal thalamic nuclei. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.


Cite as: https://hdl.handle.net/21.11116/0000-0000-C4B9-2
Abstract
The astrocytic Ca2+ signal could be simultaneously acquired with either BOLD-fMRI or LFP signal in the rat cortex under anesthesia. Intrinsic astrocytic Ca2+ bursts spikes were detected in the cortex with suppressed spontaneous LFP and negative BOLD fMRI signal. These astrocytic Ca2+ spike events were different from the normal activity-evoked Ca2+ signal and also differentiate themselves from the lesion/stimulation-induced large-scale depolarization or spreading depression given the instantaneous whole-brain pattern and correlation with the thalamic LFP. The intrinsic astrocytic Ca2+ spike may mediate the brain states through the arousal thalamic pathway.