Elegant method to quantify chemical exchange processes for pH CEST imaging

Goerke, S; Windschuh, J; Zaiss, M; Meissner, J-E; Ladd, M; Bachert, P

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Elegant method to quantify chemical exchange processes for pH CEST imaging

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Zaiss, M
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Goerke, S., Windschuh, J., Zaiss, M., Meissner, J.-E., Ladd, M., & Bachert, P. (2017). Elegant method to quantify chemical exchange processes for pH CEST imaging. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

Cite as: https://hdl.handle.net/21.11116/0000-0000-C4BF-C

Abstract

A novel concentration-independent approach is presented to determine the pH-dependence of exchange rates employing a single CEST image of a set of model solutions at different pH. Not only the comparatively short acquisition time, but also the robustness against variations in relaxation parameters makes this modality an elegant way to determine exchange rates in vitro. The calibrated functions are required for accurate pH mapping in vivo using CEST, as well as for design of exogenous CEST contrast agents.