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Journal Article

Die Abbildung von Gehirnfunktionen über einzelne Blutgefäße mit einer multi-modalen fMRT-Plattform [Map brain function in vessels with a multi-modal fMRI platform]

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Yu, X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Yu, X. (2017). Die Abbildung von Gehirnfunktionen über einzelne Blutgefäße mit einer multi-modalen fMRT-Plattform [Map brain function in vessels with a multi-modal fMRI platform]. Jahrbuch der Max-Planck-Gesellschaft, 2016/17, 1-5.

Abstract

A multi-modal fMRI platform is developed for a better understanding of the neuron-glio-vascular interaction in normal and diseased brain states of animals. Combining the single-vessel fMRI method with optogenetics and genetically encoded calcium indicators enables to identify the specific contributions of distinct vascular and cellular components to the fMRI signal. The translational application of this work is to identify vessel-specific dynamic biomarkers of patients with vascular dementia, ranging from small vessel diseases to degenerative diseases, such as Alzheimer’s.