English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Meeting Abstract

Intrinsic network connectivity and affect dysregulation in depression

MPS-Authors
There are no MPG-Authors in the publication available
External Resource

Link
(Any fulltext)

Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Walter, M. (2017). Intrinsic network connectivity and affect dysregulation in depression. Journal of Neural Transmission, 124(10), 10-10.


Cite as: http://hdl.handle.net/21.11116/0000-0000-C544-5
Abstract
Intrinsic network connectivity shows typical abnormalities in depression, which predispose individuals to respond differently to external contexts. Importantly abnormal reactivity can be characterised both blunted positive affect and increased negative affect. The latter is also related to abnormal duration of specific neuronal states following negative information. More recent research investigates such mechanisms in the context of dynamic connectivity elicited in rest-task-rest designs. We have established different cognitive and affective challenges under which specific dynamic changes of functional network connectivity is induced. Results show distinct dynamic profiles of dorsal and ventral posterior cingulate cortex as a main hub of a core network orchestrating reallocation of attentional resources. These mechanisms were shown to depend on subject characteristics including coping style and personality markers. In a clinical group of depressed patients, we found increased tonic reactivity towards attachment related stressors and in both patients and controls, dynamic state trajectories were accompanied by dynamic changes in EEG signatures concurrently recorded during fMRI.